Category: SAB Report

Galvanizing Neuroimmunity: Implication for Perioperative Neurocognitive Disorders
by Niccolò Terrando, B.Sc. (hons), D.I.C., Ph.D.

The nervous system connects to virtually every cell in the body, and regulates remote organ function via rapid and fine-tuned circuits. The vagus nerve, a major component of the bidirectional communication between the brain and peripheral organs, is one of the best-studied circuits for central/peripheral neuro/immune interactions.

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The Dichotomous Role of the Mitochondrial Permeability Transition Pore
by Matthew Barajas, MD and Richard J. Levy, MD, FAAP

The mitochondrion is a dynamic organelle that maintains cellular homeostasis by generating high-energy phosphates, buffering intracellular calcium, and modulating oxidative stress. However, mitochondria are also capable of mediating programmed cell death and necrosis. Central to many of these regulatory functions is the mitochondrial permeability transition pore (mPTP). Mounting evidence suggests that permeability transition (opening of the pore) within mitochondria plays a pathological role in a variety of cardiac disease processes and neurodegenerative states while physiological regulation of the mPTP has recently been shown to be important for cellular development and differentiation.

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Mitochondria and Bioenergetics in Health and Disease: It’s Not Just a Power Failure
by Y.S. Prakash, MD, PhD

The 65th AUA Annual Meeting was recently held in Chicago, IL. For the third year, we celebrated the successful alignment of the AUA and the IARS in furthering the science of anesthesiology and perioperative medicine by holding a joint AUA-IARS symposium. This year, the topic was “Mitochondria and Bioenergetics in Health and Disease: It’s Not Just a Power Failure”.

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Mesenchymal Stem Cell Transplantation: A New Way to Prevent Opioid Tolerance?
by Jianguo Cheng, MD, PhD, FIPP

Opioid tolerance (OT) and opioid-induced hyperalgesia (OIH) are commonly associated with opioid therapy to treat acute, chronic, and cancer pain. Opioid overdose and deaths are directly related to the development of OT, which is a physiological response to repeated exposure to opioids and requires escalating dose to achieve the desired analgesic effects. In contrast to analgesic tolerance, tolerance to the side effects of opioid therapy such as respiratory depression and constipation does not readily develop.

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